WebSialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure. WebWe show that sialyl-Tn expression induces a decrease of cell growth and adhesion, and an increase of cell migration in sialyl-Tn positive clones compared to mock transfected cells. …
Sialyl Tn-expressing bladder cancer cells induce a
WebThis distribution promotes the synthesis of the sialyl-Tn antigen while blocking the synthesis of core 1. 246 The expression levels of sialyl-Tn antigen as well as that of ST6GalNAc-I were found to be associated with decreased cell adhesion and increased cell migration of human breast cancer cells MDA-MB-231. 247,248 The sialyl-Tn-positive … WebSialyl-Tn antigen was frequently expressed in cholangiocarcinoma without cirrhosis compared with cholangiocarcinoma with cirrhosis and combined hepatocellular … smart card w laptopie
Glycoprotein screening in colorectal cancer based on differentially ...
WebMay 12, 2009 · Sialyl-Tn (STn) is expressed by 25–30% of breast carcinomas but its expression on normal tissue is highly restricted. Sialyl-Tn is an O-linked disaccharide that … WebFeb 9, 2024 · In particular, neosynthesis and over-modification of simple mucin-type O-glycans, such as the Tn antigen (GalNAc-Ser/Thr), Sialyl Tn antigen (Siaα2-6GalNAc-Ser/Thr; STn), and T antigen (Galβ1-3GalNAc-Ser/Thr), play important roles in tumor progression and malignancy in various cancers, and are associated with changes in protein conformation … WebTn, sialyl-Tn, and T are cell membrane-bound mucin-like carbohydrate structures that may be expressed in tumours due to blocked synthesis of the core carbohydrate chain of mucin-like structures. Their expression is strongly associated with prognosis in certain tumours, but the biological relationship between their expression and tumour progression is at … hillary mccaskey enneagram