WebBoth the extracts and the fractions possessed potent antitumor activity against solid tumor models by significantly reducing the solid tumor weight and volume. AB - In the present study, the root nodules of Premna herbacea Roxb. (PH) was investigated for its in vitro cytotoxicity and in vivo antitumor activity. WebHere, we report the identification, structure optimization, and structure-activity relationship studies of quinazoline derivatives as novel selective EGFR L858R/T790M inhibitors. The most promising compound, 28f , exhibited strong inhibitory activity against EGFR L858R/T790M (IC50 = 3.5 nM) and greater than 368-fold selectivity over EGFR WT (IC50 = …
Induction of mitophagy-mediated antitumor activity with folate …
Web13P - SY-5609, a highly potent and selective oral CDK7 inhibitor, exhibits robust antitumor activity in preclinical models of KRAS mutant cancers as a single agent and in … Web4 Apr 2024 · In summary, we have discovered SNV-001, a potent and selective PARP1 inhibitor and trapper that shows excellent activity against cancer models with HRD in vitro and in vivo. These data support... markdown 插入 pdf
Local delivery of optimized nanobodies targeting the PD-1/PD-L1 …
WebAmong these inhibitors, the most potent compound 8t showed excellent inhibitory activities against SHP2 (IC50 = 20.4 nM) and HDAC1 (IC50 = 25.3 nM). In particular, compound 8t exhibited improved antitumor activities compared … Web21 Mar 2024 · Our data provide convincing evidence of the antitumor activity of ensartinib against METex14 NSCLCs. Ensartinib was shown to be highly efficacious, with an ORR of 69% and DCR of 93% in our total population, with highly reproducible results from two … WebAs a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1 H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK … markdown 数式 vscode