Pd- d/e xk nuclease superfamily

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August undefined, 2024

Splet18. feb. 2005 · The PD-(D/E)XK domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly in nucleases with diverse biological functions. The … Splet20. jun. 2007 · Restriction endonuclease-like proteins, also called a PD- (D/E)XK nucleases, constitute a large and diverse superfamily of enzymes that are involved in numerous nucleic acid cleavage events important for various cellular processes.

Activity and Specificity of the Bacterial PD-(D/E)XK Homing ...

SpletThe PD-(D/E)XK nuclease domains, initially identified in type II restriction enzymes, serve as models for ... degree of amino acid conservation hampers the possibility of identification of PD-(D/E)XK superfamily members based solely on sequence comparisons. In several proteins implicated in DNA recombination and repair the restriction enzyme ... Splet15. okt. 2024 · In most PD- (D/E)xK nucleases, the negatively charged aspartate and glutamate residues help coordinate up to 3 metal ions that serve as Lewis acids to stabilize the transition state, while lysine functions as a general base for deprotonation of the nucleophilic water molecule ( SI Appendix, Fig. S2) ( 21, 24 ). boohooman sweatpants

A modular effector with a DNase domain and a marker for T6SS

Splet13. jan. 2013 · The key motifs of the PD−(D/E)XK nuclease superfamily are indicated with Roman numerals, and the sequence details for the motifs characteristic of the RecB-type subgroup are shown as colored ... SpletNational Center for Biotechnology Information Splet01. feb. 2001 · The PD- (D/E)XK nuclease domains, initially identified in type II restriction enzymes, serve as models for studying aspects of protein-DNA interactions, mechanisms … boohooman swim shorts

Structural insights into DNA degradation by human mitochondrial ...

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SpletLOCUS NC_021776 42313 bp DNA linear PHG 08-JAN-2024 DEFINITION Vibrio phage vpms1, complete genome. ACCESSION NC_021776 VERSION NC_021776.1 DBLINK BioProject: PRJNA485481 KEYWORDS RefSeq. Splet18. feb. 2005 · The PD- (D/E)XK domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly in nucleases with diverse biological functions. The first structurally characterized members of the PD- (D/E)XK superfamily were restriction enzymes (REases) (reviews: [ 1, 2 ]). godinger brass charger platesSplet12. jul. 2005 · The PD- (D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is … boohooman tops

"Splet19. jun. 2007 · Several unique protein folds that catalyze the hydrolysis of phosphodiester bonds have arisen independently in nature, including the PD(D/E)XK superfamily (typified … " - Pd- d/e xk nuclease superfamily

Pd- d/e xk nuclease superfamily

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SpletPD- (D/E)XK nuclease superfamily Members of this family belong to the PD- (D/E)XK nuclease superfamily Links ? Statistics ? Structure ? PubMed References pfam12705 is … SpletThe PD- (D/E)XK phosphodiesterases span over 21,900 proteins, which can be classified into 121 groups of various families. Eleven of them, including DUF4420, DUF3883, …

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Splet20. jun. 2007 · PD-(D/E)XK nucleases constitute a large and highly diverse superfamily of enzymes that display little sequence similarity despite retaining a common core fold and … Splet12. jul. 2005 · BackgroundThe PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is one of the most challenging targets for protein sequence analysis and …

Splet07. okt. 2016 · Kosinski J, Feder M, Bujnicki JM. The PD-(D/E)XK superfamily revisited: Identification of new members among proteins involved in DNA metabolism and functional predictions for domains of (hitherto) unknown function. BMC Bioinformatics. 2005; 6:172. doi: 10.1186/1471-2105-6-172; pmid: 16011798. [PMC free article] [Google Scholar] Splet06. feb. 2009 · The primary evolutionary advantage for the PD-(D/E)XK nuclease superfamily is its stable and multifunctional core fold, which orients catalytic residues in optimal geometry for a phosphoryl transfer reaction while providing a highly adaptable surrounding scaffold that can easily accommodate additional structural elaborations. …

SpletThe crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily. J. Virol., 84:5890-5897, 2010. Cited by . PubMed: 20375162 DOI: 10.1128/JVI.01663-09 PDB entries with the same primary citation: Experimental method: SpletThe PD- (D/E)XK nuclease domains, initially identified in type II restriction enzymes, serve as models for studying aspects of protein-DNA interactions, mechanisms of phosphodiester hydrolysis, and provide indispensable tools for techniques in genetic engineering and molecular medicine.

Splet01. avg. 2012 · The PD-(D/E)XK phosphodiesterases span over 21 900 proteins, which can be classified into 121 groups of various families. Eleven of them, including DUF4420, …

Splet12. jul. 2005 · BackgroundThe PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and … boohoo manteau petiteSplet09. avg. 2024 · PoNe belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. godinger blush wine glassesSpletThe PD-(D/E)XK nuclease domains, initially identified in type II restriction enzymes, serve as models for studying aspects of protein-DNA interactions, mechanisms of phosphodiester … boohooman telephone number