Ctgf in ssc

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August undefined, 2024

WebJun 29, 2009 · Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic sclerosis (SSc) and has been hypothesized to be a key mediator of the pulmonary fibrosis frequently observed in this disease. CTGF is induced by transforming growth factor β (TGFβ) and is a mediator of some profibrotic effects of TGFβ in vitro. WebA drawback to using Col1a2-CTGF mouse to study human SSc is perhaps that SSc onset often occurs later in life, and when the CTGF gene is upregulated constitutively in Col1a2-CTGF mice, profound changes are likely to have already occurred from birth given the role of CTGF in development (Canalis et al., 2010; Nagashima et al., 2011).

Selective stimulation of collagen synthesis in the presence of

WebUnited States » Georgia » Fulton County » Atlanta ». Professional & Other Places » Office. Make sure your information is up to date. Plus use our free tools to find new … Web系统性硬化病(systemic sclerosis，SSc)是一种以皮肤增厚和纤维化及胃肠道、肺、心、血管等多个系统受累为特征的自身免疫性疾病。 SSc的病因及发病机制十分复杂，目前认为病因与遗传和环境因素有关，发病机制包括血管病变、免疫系统功能失调、纤维化及3者间的 ... easel tabletop stand

Role of Endothelial to Mesenchymal Transition in the ... - Hindawi

Web관련정보(바로가기) 온양화탁통락방(温阳化浊通络方) 임상시험 원제 : 温阳化浊通络方治疗系统性硬化... WebObjective: To conduct a replication study to investigate whether the −945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. Methods: The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case–control sets of European ancestry (Spanish, French, … Web817-222-5966 (FAX) Western Service Center. 2200 S. 216th St. Des Moines, WA 98198-6547. 206-231-2420. The role of the Service Center is to provide shared services which … easel that turns into a table

Association Between a CTGF Gene Polymorphism and …

The CTGF -945GC polymorphism is not associated with plasma CTGF …

WebConnective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patien … easel that holds paperWebJun 13, 2024 · Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the therapeutic potential of targeting CTGF in … easel tops

"WebFibrotic diseases such as scleroderma (systemic sclerosis, SSc) are characterized by an excessive production of extracellular matrix and profibrotic proteins such as connective tissue growth factor (CTGF). … " - Ctgf in ssc

Ctgf in ssc

Constitutive Connective Tissue Growth Factor Expression …

WebAlthough the precise molecular mechanisms driving fibrosis remain elusive, TGF-beta and connective tissue growth factor (CTGF), are considered key mediators. CTGF is over-expressed in lesional tissue and enhanced levels in the circulation are an indicator of disease extent and severity. ... In animal models of SSc, neutralization of CTGF with ... WebIn SSc, serum CTGF levels correlate with the extent of skin and pulmonary fibrosis. The expression of CTGF can be induced in normal fibroblasts by TGF-β, IL-4, and VEGF, whereas TNF and prostacylins block stimulation. ... Connective tissue growth factor (CTGF or CCN2) is a prototypic member of the CCN family of cytokines. The CCN family …

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WebNational Center for Biotechnology Information WebJul 14, 2013 · Connective Tissue Growth Factor (CTGF), also known as CCN2, is another pleotropic growth factor that has emerged as an important mediator of normal and pathological tissue fibrotic responses [171–174] and has been suggested to play a crucial role in SSc tissue fibrosis.

WebSep 28, 2014 · Scleroderma (systemic sclerosis, SSc) is a fibrotic disease for which there is no therapy. CCN2 (connective tissue growth factor, CTGF) is a marker and mediator of fibrosis. WebApr 1, 2024 · Connective tissue growth factor (CTGF), a member of CCN family, ... Some studies have tried to analyze the relationship between CTGF and SSc deeply in the level of the gene. In the previous study, the polymorphism (G-945C) in the promoter of CTGF gene was tested. It was found that −945G allele was important for the susceptibility to SSc.

Web1 The abbreviations used are: TGFβ, tumor growth factor-β; SSc, scleroderma; CTGF, connective tissue growth factor; CMV, … Web结缔组织生长因子在硬皮病患者皮肤组织上的表达研究.pdf

WebNov 23, 2024 · Connective tissue growth factor (CTGF) is an important mediator in fibrotic disease. Single nucleotide polymorphisms (SNPs) in CTGF have been found to be a ... hepatic fibrosis and SSc. An association of CTGF rs6918698GG (equals to the CC in our study) with susceptibility to SSc was found in a British and Asian cohort (see material …

WebJul 19, 2024 · Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin … easel the weaselWebSep 10, 2008 · Connective tissue growth factor (CTGF), also know as CCN2, is a small cyteine-rich secreted multi-modular protein, ... Several approaches have been employed for antagonizing, blocking or inhibiting CTGF activity. In the context of SSc-associated lung disease, hepatocyte growth factor has been shown to down-regulate CTGF expression … easel toys r usWebFeb 1, 2010 · Objective. Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by chronic fibrosis of the skin and internal organs. Connective tissue growth factor (CTGF) is believed to … easel teachingWebFeb 1, 2000 · Methods: The expressions of hypoxia-inducible factor 1 alpha (HIF-1α) and connective tissue growth factor (CTGF) in skin specimens derived from SSc patients and healthy volunteers were examined ... ct-th1WebJun 13, 2024 · Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) … ct-th-2WebAug 1, 2024 · Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. ... The role of CTGF in SSc fibroblasts is reported ... ctth annual report 2021WebMar 3, 2024 · Objective: To examine the mechanism of collagen induction by connective tissue growth factor (CTGF), a profibrotic cytokine overexpressed in the skin of patients with systemic sclerosis (SSc). Methods: Dermal fibroblasts from 7 SSc patients and 7 matched healthy adult donors were stimulated with CTGF in the presence or absence of … ct-th2 cad