Camptothecin mw
WebApr 13, 2024 · The fabrication of pH-sensitive lignin-based materials has received considerable attention in various fields, such as biomass refining, pharmaceuticals, and detecting techniques. However, the pH-sensitive mechanism of these materials is usually depending on the hydroxyl or carboxyl content in the lignin structure, which hinders the … WebCamptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing …
Camptothecin mw
Did you know?
WebCamptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian … WebCamptothecin, Camptotheca acuminata - CAS 2114454. BRD-A30437061-001-01-9. BRD-A30437061-001-04-3. Q27163449. 4-Ethyl-4-hydroxy-1H,12H-6,12a-diaza-2-oxa-13H-dibenzo [b,h]fluorene-3,13 (4H) …
WebAug 21, 2009 · Human serum was spiked with camptothecin and the sample injected in a mixture of 250 μl each of upper and lower layer. Fig. 8 depicts the chromatogram of this run. As an extracted ion chromatogram at m/z = 349 shows, camptothecin, of MW 348, elutes at 37.9 min, or nearly identical to its elution time from dog bile. In this solvent system, the ... Web(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. …
WebMW 348.35. Cell-permeable DNA topoisomerase inhibitor. Potent antitumour and antibiotic agent. Achieve your results faster with highly validated, pure and trusted compounds. ... The cells were incubated at 37°C for 3h in media containing different concentrations of ab120115 (camptothecin) in DMSO, fixed with 4% formaldehyde for 10 minutes at ... WebJan 4, 2005 · Camptothecin- and etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and -4 aggregation but accelerates tumor necrosis factor–related apoptosis-inducing ligand–mediated cell death Molecular Cancer Therapeutics American Association for Cancer Research Article ARTICLE January 04 …
WebIt is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other …
WebDescription: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. … can car seats go in the front seatWebJan 15, 2024 · As a famous quinoline alkaloid, camptothecin (CPT) presented the significant anti-tumor activity, as well as the interesting insecticidal activities, but the low … fishing pier hilton head islandWebMay 22, 2024 · Molecular weight isolated CPT exactly matches with standard molecular weight of camptothecin, i.e., 349.2 [35, 36]. NMR spectroscopy mainly determines … fishing pier deerfield beach flWebCamptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminate, is a potent cytotoxic agent, acting by the inhibition of DNA topoisomerase I [107]. Numerous derivatives of camptothecin have been synthesized in order to improve its pharmacological profile for effective anti‐tumour drugs. fishing pierce pond maineWebDownload scientific diagram Structures of Camptothecin (1, MW 348) and its analogues (2, MW 365; 3, MW 378). from publication: The Anti-HIV Actions of 7- and 10-Substituted Camptothecins ... fishing pier fort myers beachWebCamptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985). TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I. For in vitro cleavage detection, we recommend that the drug be tested in the range 100 uM ... can carthart jacket be washedWebMolecular Weight (g/mol) 348.35: MDL Number: MFCD00081076: InChI Key: VSJKWCGYPAHWDS-FQEVSTJZSA-N: Synonym: camptothecin, camptothecine, s-+ … can cars stay overnight at truck stops